Nature Publishing Group (NPG) is a publisher of high impact scientific and medical information in print and online. NPG publishes journals, online databases, and services across the life, physical, chemical and applied sciences and clinical medicine. Focusing on the needs of scientists, Nature (founded in 1869) is the leading weekly, international scientific journal. In addition, for this audience, NPG publishes the Nature research journals and Nature Reviews journals, plus a range of prestigious academic journals including society-owned publications. Online, nature.com provides over 6 million visitors per month with access to NPG publications and online databases and services, including news and comment from Nature, NatureJobs plus access to Nature Network and Nature Education`s Scitable.com. Sign up for your free copy of Nature Outlook: Tuberculosis. Drug resistance and the HIV pandemic have thwarted efforts to rid the world of humanity`s biggest killer Mycobacterium tuberculosis. We need new types of safe drug, a practical point of-care diagnostic and ultimately an effective vaccine if we are ever to eliminate tuberculosis. But first we need a better understanding of the underlying biology.